Paraxanthine Choline Salt combines paraxanthine and choline in a salt-form ingredient. Its formulation rationale is to improve aqueous handling while introducing both components through one raw material.
Why consider the salt form?
For beverage and liquid supplement developers, solubility can influence ingredient loading, mixing and the risk of precipitation. The supplier reports the following in vitro results:
| Ingredient | Reported Water Solubility |
|---|---|
| Paraxanthine | 2 mg/mL |
| Paraxanthine Choline Salt | 354 mg/mL |
Values are reproduced from supplier data. Test temperature, pH and concentration basis require confirmation. Performance in the finished formulation should be evaluated separately.
Ingredient research
| Research Area | Evidence Summary |
|---|---|
| Attention & Cognitive Performance | A randomized crossover study in 13 healthy adults evaluated 200 mg paraxanthine and reported improvements in selected measures of short-term memory, reasoning and sustained attention. |
| Cognitive Performance Around Exercise | A randomized crossover study in 12 trained runners evaluated paraxanthine before a 10-km run and reported benefits in selected measures of post-exercise reaction time and vigilance. |
| Choline Nutrition | Choline is an essential nutrient involved in cell-membrane phospholipid synthesis and methyl-group metabolism. |
The human studies above evaluated paraxanthine, not this choline salt. They provide ingredient-level context rather than clinical validation of the supplied product.
Salt-specific preclinical data
The supplier reports that, in an equimolar oral study in rats, paraxanthine plasma exposure measured by AUC was approximately 2.5 times that of free paraxanthine. This finding concerns animal pharmacokinetics; its relevance to human absorption and efficacy remains to be established.
| Application | Development Focus | Formats to Evaluate |
|---|---|---|
| Functional Beverages | Ingredient loading, clarity, pH compatibility and shelf stability | RTD beverages, concentrated shots |
| Sports Nutrition | Active-content targets, flavor compatibility and mixing performance | Pre-workout powders, drink mixes |
| Focus Formulations | Serving-size design and compatibility with other ingredients | Capsules, tablets, liquid supplements |
| Powdered Beverages | Reconstitution, moisture sensitivity and packaging protection | Stick packs, sachets |
These are formulation development directions. Suitability depends on product testing and the requirements of the intended market.
Can this replace free paraxanthine at the same ingredient weight?
Calculate the required input from the target paraxanthine amount and the verified batch assay. Include the accompanying choline contribution in the overall formulation.
Will it remain clear in an acidic beverage?
Water-solubility results alone do not establish beverage stability. Evaluate the intended concentration, pH, other ingredients, processing conditions and storage period.
Which documents should I request for supplier qualification?
Request the current specification, batch COA, SDS, analytical methods, supporting test reports and applicable certification details.
Product Name: PRAXPULSE™ Paraxanthine
CAS No.: 611-59-6
Purity: ≥ 99.0% HPLC
Assay: ≥ 99.0% HPLC
Appearance: Light Yellow Powder
Certification: ISO9001/FSSC22000/HALAL/KOSHER
GRAS Status: SELF-GRAS Obtained
Product Name: BerVic™ Berberine Vitamin C Salt
Appearance: Yellow Powder
USPTO No.: US11345697B1
Registered in FDA
FDA “Certificate of Free Sale”
Product Name: Paraxanthine Choline Salt
Appearance: Light yellowpowder
Purity: 99.6%
Assay (NMR):
Certification:
(available upon request)
