Cellular Anti-Aging & Age Retardation
- Mechanism of Action: Activates cellular autophagy, preserves telomere length and alleviates oxidative stress.
- Scientific Evidence: Studies have proven that spermidine supplementation extends the lifespan of various model organisms, and is significantly correlated with reduced mortality in humans
(Kiechl, S., et al. (2018). Higher salivary spermidine levels are associated with longevity in humans. The American Journal of Clinical Nutrition, 108(2), 371–380.)
Cognitive & Neurological Support
- Mechanism of Action: Crosses the blood-brain barrier, clears beta-amyloid plaques and sustains synaptic plasticity.
- Clinical Evidence: A randomized, double-blind, placebo-controlled clinical trial demonstrates that spermidine supplementation notably improves cognitive. performance and memory in elderly individuals with dementia
(Wirth, M., et al. (2018). Effects of spermidine supplementation on cognition and biomarkers in older adults with memory decline. Alzheimer's & Dementia, 14(7), P1183.)
(Pekar, T., et al. (2021). The positive effect of spermidine in older adults with dementia: A randomized, double-blind, placebo-controlled trial. Wiener Klinische Wochenschrift, 133(9), 484–491.)
Cardiovascular Protection
- Mechanism of Action: Boosts nitric oxide production, improves vascular endothelial function and alleviates myocardial hypertrophy.
- Scientific Evidence: Research indicates that dietary spermidine helps lower blood pressure by maintaining vascular elasticity and reduces the risk of cardiovascular diseases
(Eisenberg, T., et al. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine, 22(12), 1428–1438.)
Hair Growth & Skin Vitality
- Mechanism of Action: Stimulates epithelial stem cells and prolongs the anagen phase of hair follicles.
- Clinical Evidence: Clinical evaluations confirm that spermidine effectively promotes human hair shaft growth and enhances skin barrier function.
(Rinaldi, F., et al. (2011). A randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a spermidine-based nutritional supplement in human hair growth. Dermatology Practical & Conceptual, 1(1), 15–22.)
(Ramot, Y., et al. (2011). Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PLOS ONE, 6(7), e22564.)
