
Berberine Hydrochloride (Berberine HCl) has severely limited applications in dietary supplements due to its extremely low solubility and bioavailability. The novel compound, Berberine Vitamin C Salt (Berberine VC Salt), not only completely eliminates chloride ions (Chloride-Free), but also achieves a leapfrog upgrade in both dissociation rate and absorption. It provides stable and long-lasting support for blood glucose management, weight control, and gut health. It stands as the premier alternative for global innovative formulators seeking a highly efficient, non-irritating berberine solution.
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100×
Water Solubility Increase
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5–7×
Bioavailability Enhancement
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0
Chloride Ions (Chloride-Free)
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Berberine Hydrochloride (Berberine HCl) has extremely low water solubility at room temperature — only approximately 0.50 mg/mL — and easily forms suspensions in the intestinal tract, resulting in an oral bioavailability that is typically below 1%. This frequently forces consumers to take large doses, which can trigger gastrointestinal discomforts such as diarrhea, abdominal bloating, and distress.
It perfectly combines natural berberine with highly active Vitamin C to form a brand-new salt structure. Its solubility in water at room temperature surges to 100.32 mg/mL — over 100 times that of berberine hydrochloride! This innovative, chloride-free form bypasses the intestinal intolerance barrier, allowing high-purity active ingredients to be instantly absorbed and efficiently utilized by the body.
| Comparative Metrics | Bervic"™ Berberine Vitamin C Salt | Berberine Hydrochloride (HCl) |
| Physical Form | Bright yellow-orange fine powder | Standard light-yellow powder |
| Water Solubility (RT) | ≥ 100.32 mg/mL (100-fold increase) | 0.50 mg/mL (Extremely poorly soluble) |
| Dissolution Performance | Dissolves fully and instantly; solution is clear and sediment-free | Low solubility; easily forms a turbid suspension in water |
| Relative Bioavailability | Enhanced 5-7 times (Mean AUC:9087) | Baseline of 1 (Mean AUC: 1545) |
| Formulation Compatibility | ✅️Exceptionally High | ❌️Restricted; cannot be used in liquid dosage forms due to poor solubility and Gl irritation |
| Gastrointestinal Tolerance | ✅️Chloride-free, gentle on the stomach, completely absorbed | ❌️Residual suspensions irritate the intestinal mucosa, easily causing diarrhea and bloating |
Benefiting from the introduction of Vitamin C, Berberine Vitamin C Salt not only possesses the metabolic regulatory properties of standard berberine but also provides additional antioxidant support.
A study published in the top-tier journal Cell Metabolism (2026) demonstrates that Vitamin C can clear free radicals and effectively reverse the biological age of multiple organs in primate models by targeting and inhibiting the ACSL4 enzyme to block "ferroptosis." This dual-action mechanism ensures robust liver health and long-term cardiovascular maintenance alongside blood glucose and lipid management.
Mechanism of Action: Berberine is a universally recognized natural AMPK activator. Utilizing its ultra-high bioavailability, Bervic™ improves insulin sensitivity more efficiently, promoting glucose uptake and fatty acid oxidation in skeletal muscle and the liver.
Mechanism of Action: The unique Vitamin C salt structure not only works synergistically to reduce systemic inflammation but also gently modulates the gut microbiota. It promotes the growth of probiotics and safeguards the intestinal barrier, fundamentally eliminating the adverse gastrointestinal side effects commonly caused by standard berberine formulations.

Product Name: PRAXPULSE™ Paraxanthine
CAS No.: 611-59-6
Purity: ≥ 99.0% HPLC
Assay: ≥ 99.0% HPLC
Appearance: Light Yellow Powder
Certification: ISO9001/FSSC22000/HALAL/KOSHER
GRAS Status: SELF-GRAS Obtained
Product Name: BerVic™ Berberine Vitamin C Salt
Appearance: Yellow Powder
USPTO No.: US11345697B1
Registered in FDA
FDA “Certificate of Free Sale”