BERVIC™ Berberine Vitamin C Salt

BERVIC™ Berberine Vitamin C Salt
Product Name: BerVic™ Berberine Vitamin C Salt
Appearance: Yellow Powder
USPTO No.: US11345697B1
Registered in FDA
FDA “Certificate of Free Sale”

NOVEL CRYSTAL FORM BERBERINE VITAMIN C SALT

Berberine Hydrochloride (Berberine HCl) has severely limited applications in dietary supplements due to its extremely low solubility and bioavailability. The novel compound, Berberine Vitamin C Salt (Berberine VC Salt), not only completely eliminates chloride ions (Chloride-Free), but also achieves a leapfrog upgrade in both dissociation rate and absorption. It provides stable and long-lasting support for blood glucose management, weight control, and gut health. It stands as the premier alternative for global innovative formulators seeking a highly efficient, non-irritating berberine solution.

 

100×
Water Solubility Increase
5–7×
Bioavailability Enhancement
0
Chloride Ions (Chloride-Free)

Why Choose BERVIC™ Over Berberine Hydrochloride?

Berberine HCl: Extremely Low Solubility & Bioavailability

Berberine Hydrochloride (Berberine HCl) has extremely low water solubility at room temperature — only approximately 0.50 mg/mL — and easily forms suspensions in the intestinal tract, resulting in an oral bioavailability that is typically below 1%. This frequently forces consumers to take large doses, which can trigger gastrointestinal discomforts such as diarrhea, abdominal bloating, and distress.

Bervic™: 100× Solubility & Chloride-Free

It perfectly combines natural berberine with highly active Vitamin C to form a brand-new salt structure. Its solubility in water at room temperature surges to 100.32 mg/mL — over 100 times that of berberine hydrochloride! This innovative, chloride-free form bypasses the intestinal intolerance barrier, allowing high-purity active ingredients to be instantly absorbed and efficiently utilized by the body.

Superior Advantages of BERVIC™ BERBERINE VITAMIN C SALT

Comparative Metrics Bervic"™ Berberine Vitamin C Salt Berberine Hydrochloride (HCl)
Physical Form Bright yellow-orange fine powder Standard light-yellow powder
Water Solubility (RT) ≥ 100.32 mg/mL (100-fold increase) 0.50 mg/mL (Extremely poorly soluble)
Dissolution Performance Dissolves fully and instantly; solution is clear and sediment-free Low solubility; easily forms a turbid suspension in water
Relative Bioavailability Enhanced 5-7 times (Mean AUC:9087) Baseline of 1 (Mean AUC: 1545)
Formulation Compatibility ✅️Exceptionally High ❌️Restricted; cannot be used in liquid dosage forms due to poor solubility and Gl irritation
Gastrointestinal Tolerance ✅️Chloride-free, gentle on the stomach, completely absorbed ❌️Residual suspensions irritate the intestinal mucosa, easily causing diarrhea and bloating

BerVic™ Benefits & Scientific Backing

Powered by Vitamin C: Dual Antioxidant Action

Benefiting from the introduction of Vitamin C, Berberine Vitamin C Salt not only possesses the metabolic regulatory properties of standard berberine but also provides additional antioxidant support.

A study published in the top-tier journal Cell Metabolism (2026) demonstrates that Vitamin C can clear free radicals and effectively reverse the biological age of multiple organs in primate models by targeting and inhibiting the ACSL4 enzyme to block "ferroptosis." This dual-action mechanism ensures robust liver health and long-term cardiovascular maintenance alongside blood glucose and lipid management.

Glucose Optimization & Weight Management

Mechanism of Action: Berberine is a universally recognized natural AMPK activator. Utilizing its ultra-high bioavailability, Bervic™ improves insulin sensitivity more efficiently, promoting glucose uptake and fatty acid oxidation in skeletal muscle and the liver.

Gut Health & Anti-Inflammation

Mechanism of Action: The unique Vitamin C salt structure not only works synergistically to reduce systemic inflammation but also gently modulates the gut microbiota. It promotes the growth of probiotics and safeguards the intestinal barrier, fundamentally eliminating the adverse gastrointestinal side effects commonly caused by standard berberine formulations.

Applications of BerVic™

FAQ

What is Berberine Vitamin C Salt?

Berberine Vitamin C Salt is a patented novel berberine salt developed by Youyou Biotech. It is protected by U.S. Patent No. US11345697B1 and was developed through innovative salt-form technology to improve the physicochemical properties of berberine.

What are the key advantages of Berberine Vitamin C Salt?

Key advantages include: 50–100× higher water solubility compared with Berberine HCl Nearly 6× higher bioavailability compared with Berberine HCl U.S. crystal form patent protection These characteristics provide brands with a differentiated berberine ingredient solution.

Is there scientific evidence supporting its enhanced bioavailability?

Yes. A pharmacokinetic study comparing Berberine Vitamin C Salt and Berberine HCl showed: Cmax: 3277 ng/mL vs 531 ng/mL AUC₀-t: 9087 ng·h/mL vs 1545 ng·h/mL The results demonstrated significantly higher systemic exposure of Berberine Vitamin C Salt compared with Berberine HCl.

Why choose Berberine Vitamin C Salt for product development?

As the berberine market continues to grow, brands are seeking more differentiated ingredient solutions beyond conventional Berberine HCl. Berberine Vitamin C Salt provides a next-generation innovation platform through patented technology, enhanced solubility, and improved bioavailability.

How is Berberine Vitamin C Salt different from Berberine HCl?

Berberine Vitamin C Salt features a unique Vitamin C salt form and crystal structure that differentiates it from Berberine HCl. Compared with Berberine HCl, it demonstrates improved solubility and significantly enhanced systemic exposure in pharmacokinetic evaluation.

Inquiry

+86-180 1489 7118sales@uubiotech.com
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