Deoxynojirimycin Hydrochloride

Deoxynojirimycin hydrochloride (DNJ HCL) is an orally effective α-glucosidase inhibitor. DNJ HCL can suppress postprandial blood glucose levels and help prevent diabetes. It possesses multiple functions, including lowering blood sugar, promoting weight loss, and exhibiting antiviral activity. With increasing research in these areas, DNJ has gradually gained public attention.

DNJ is a potent α-glucosidase inhibitor. It structurally resembles glucose and competitively binds to digestive enzymes responsible for carbohydrate breakdown.

Mechanism of Action: inhibits α-glucosidase activity in the small intestine; delays conversion of complex carbohydrates into absorbable glucose; slows glucose absorption after meals; reduces postprandial blood glucose spikes; supports insulin sensitivity and glucose utilization; promotes GLP-1 related metabolic benefits; helps reduce metabolic stress associated with obesity and aging.

Blood Glucpse Control

Helps maintain healthy blood sugar levels after meals by slowing carbohydrate conversion to glucose, resulting in reduced glucose spikes and better glycemic control.

(Li, YG., Ji, DF., Zhong, S. et al. 1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice. Sci Rep 3, 1377 (2013).)

Weight Management

Supports healthy body weight and appetite regulation; research suggests DNJ influences GLP-1 related pathways and improves glucose metabolism.This helps reduce fat accumulation and improve energy utilization.

（Kim, Jongwan, Yun, Eun-Young, Quan, Fu-Shi, Park, Seung-Won, Goo, Tae-Won, Central Administration of 1-Deoxynojirimycin Attenuates Hypothalamic Endoplasmic Reticulum Stress and Regulates Food Intake and Body Weight in Mice with High-Fat Diet-Induced Obesity, Evidence-Based Complementary and Alternative Medicine, 2017, 3607089, 11 pages, 2017. )

Insulin Sensitivity Support

It helps improve insulin function and glucose uptake. Studies have shown that DNJ can promote insulin secretion, and reduce insulin resistance associated with metabolic disorders.

(Xinxiu Ren, Yan Xing, Liangyu He, Zhilong Xiu, Ling Yang, Aizhi Han, Qinhua Jia, Yuesheng Dong,Effect of 1-Deoxynojirimycin on insulin resistance in prediabetic mice based on next-generation sequencing and intestinal microbiota study,Journal of Ethnopharmacology, Volume 289,2022,115029,ISSN 0378-8741,）

Healthy Aging

By promoting glucose homeostasis, it may help reduce oxidative stress and glycation-related metabolic aging processes.

(Kiran Thakur, Yuan-Yuan Zhang, Andrei Mocan, Fang Zhang, Jian-Guo Zhang, Zhao-Jun Wei,1-Deoxynojirimycin, its potential for management of non-communicable metabolic diseases,Trends in Food Science & Technology,Volume 89,2019,Pages 88-99,ISSN 0924-2244,）